(S)-(-)-2-Methyl-CBS-oxazaborolidine solution, 1 M in toluene

Application

CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis

(S)-(-)-2-Methyl-CBS-oxazaborolidine solution [1M in toluene] may be used as a catalyst in the multi-step synthesis of (-)-diospongin A.It may also be used in the preparation of:(1S)-2-azido-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol(R)-α-deuteriobenzyl alcohol(R)-2-(1-hydroxyethyl)benzo[b]thiophene

Excellent catalyst for asymmetric reductions.

The CBS (Corey-Bakshi-Shibata) oxazaborolidine catalyst has been used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C₂-symmetrical ferrocenyl diols, and propargyl alcohols.

Catalyst employed in an enantioselective synthesis of (S)-2-amino-1-phenylethanol.

Other Notes

Precipitate may form in storage, but does not affect product quality. Gently heat product to 80-90 °C under an inert atmosphere to redissolve solids.

Packaging

5 mL in glass bottle

25 mL in Sure/Seal™