Biochem/physiol Actions

Cell permeable: no

Reversible: no

Product does not compete with ATP.

Primary TargetAnti-tumor and antiparasitic properties

General description

An estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.

An estrogenic flavonoid with anti-tumor and antiparasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation, exhibits anti-tumor activity, and enhances the effect of Paclitaxel (Cat. No. 580555) and Vinblastine (Cat. No. 677175) chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Rafi, M.M., et al. 2000. Anticancer Res. 20, 2653.Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.Haraguchi, H., et al. 1998. Phytochemistry 48, 125.Park, E.J., et al. 1998. Planta Med. 64, 464.Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.

Packaging

Packaged under inert gas

10, 50 mg in Plastic ampoule

Preparation Note

Further dilute 1:10 with aqueous buffer or medium just prior to use.

Reconstitution

Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Harmful (C)