Biochem/physiol Actions
Cell permeable: no
Reversible: no
Product does not compete with ATP.
Primary TargetAnti-tumor and antiparasitic properties
General description
An estrogenic flavanoid with anti-tumor and anti-parasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation and enhances the effect of paclitaxel and vinblastine chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.
An estrogenic flavonoid with anti-tumor and antiparasitic properties. Shown to reduce Bcl-2 protein expression and induce apoptosis in several human cancer cell lines. Also induces cell differentiation, exhibits anti-tumor activity, and enhances the effect of Paclitaxel (Cat. No. 580555) and Vinblastine (Cat. No. 677175) chemotherapy. Reported to interfere with parasite mitochondrial electron transport chain and energy metabolism.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Rafi, M.M., et al. 2000. Anticancer Res. 20, 2653.Zhai, L., et al. 1999. J. Antimicrob. Chemother. 43, 793.Haraguchi, H., et al. 1998. Phytochemistry 48, 125.Park, E.J., et al. 1998. Planta Med. 64, 464.Chen, M., et al. 1994. Antimicrob. Agents Chemother. 38, 1470.Chen, M., et al. 1993. Antimicrob. Agents. Chemother. 37, 2550.
Packaging
Packaged under inert gas
10, 50 mg in Plastic ampoule
Preparation Note
Further dilute 1:10 with aqueous buffer or medium just prior to use.
Reconstitution
Following reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C.
Warning
Toxicity: Harmful (C)
This product has met the following criteria: