PHR1384-1G Display Image

Amitriptyline hydrochloride, pharmaceutical secondary standard; traceable to USP, PhEur and BP

Code: PHR1384-1G D2-231

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.


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£101.00 1G

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.


Amitriptyline hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem/physiol Actions

Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.


To see an example of a Certificate of Analysis for this material enter LRAA1640 in the slot below. This is an example certificate only and may not be the lot that you receive.

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amitriptyline hydrochloride is a drug, and a tricyclic antidepressant with anticholinergic activity. It is widely used in combination with chlordiazepoxide 7-chloro-2-(methyl-amino)-5-phenyl-3H-1,4-benzodiazepine-4-oxide for the treatment of patients with moderate to severe depression associated with moderate to severe anxiety.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

agencytraceable to BP 16, traceable to Ph. Eur. Y0000563, traceable to USP 1029002
application(s)pharmaceutical (small molecule)
CofAcurrent certificate can be downloaded
Gene Informationhuman ... SLC6A2(6530), SLC6A4(6532)
gradepharmaceutical secondary standard, certified reference material
Quality Level300
SMILES stringCl[H].CN(C)CCC=C1c2ccccc2CCc3ccccc13
storage temp.2-30°C
technique(s)gas chromatography (GC): suitable, HPLC: suitable
Cas Number549-18-8
This product has met the following criteria: