A multimodal anion exchange resin designed for post-protein A purification of monoclonal antibodies at process scale. It can also be used in bind/elute mode.
- Wide operational window of pH and conductivity.
- Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.
- Two-step chromatographic process with protein A affinity, saves time and cuts operating costs.
- Removes contaminants to formulation levels.
- High capacity and productivity in flow-through mode.
Different selectivity from traditional IEX resins
Capto adhere is composed of a rigid, high-flow agarose matrix and a novel multimodal ligand. The strong multimodal ligand gives a different selectivity compared to traditional ion exchange (IEX) resins.
Second step in mAb chromatographic process
Capto adhere can remove key contaminants such as DNA, host cell proteins (HCP), leached protein A, dimers and larger aggregates, and viruses in a single step. Together with a Protein A capture step, like MabSelect SuRe, Capto adhere allows the design of a two-step chromatographic process for mAbs.
Part of the Capto adhere family
For optimal performance of Capto adhere, screening and optimization of loading conditions is recommended, preferably using modern high-throughput process development tools, such as PreDictor 96-well filter plates.
This product has met the following criteria: