Application

Dipeptidyl peptidase IV inhibitor I has been used in acute in vivo studies to assess rapid plasma glucagon-like peptide (GLP-1) responses to specified secretory agents in mice.

Biochem/physiol Actions

Dipeptidyl peptidase IV (DPP IV) functions as a modulator of glucagon-like peptide (GLP-1), insulin-stimulating hormones, and glucose-dependent insulinotropic polypeptide (GIP). It is an essentialtherapeutic targetfortype 2 diabetes (T2DM). DPP-4 inhibitors are crucial for maintaining glucose homeostasis by prolonging the activity of GLP-1 and GIP. They also enhance glycemic control for a longer period when compared to early oralhypoglycemics.DPP-4 also acts as a binding protein and a ligand of extracellularfactors.

General description

Dipeptidyl peptidase IV (DPP IV)is a member of theprolyl-specificproteases family. It is a dimeric type II integral membrane glycoprotein that is broadly expressed intheepithelial and nonepithelial tissues. It is majorly expressedin the kidney and thecolon.

Sequence

Ile-Pro-Ile