C6645-25MG Display Image

Cytosine beta-D-arabinofuranoside hydrochloride, crystalline

Code: C6645-25MG D2-231

Application

Cytosine β-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco′s modified eagle medium (FBS-DMEM) and B27/neurobasal-A med...


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£46.50 25MG
£55.80 inc. VAT
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Application

Cytosine β-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco′s modified eagle medium (FBS-DMEM) and B27/neurobasal-A medium to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.

Biochem/physiol Actions

Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.

Packaging

100, 500 mg in glass bottle

1, 5 g in glass bottle

25 mg in poly bottle

formcrystalline
Gene Informationhuman ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558)
InChI keyKCURWTAZOZXKSJ-JBMRGDGGSA-N
InChI1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7+,8-;/m1./s1
mp197-198 °C (lit.)
Quality Level200
SMILES stringCl[H].NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O
storage temp.2-8°C
Code
Description
Unit Size
List Price
Qty
C6645-100MG
Cytosine beta-D-arabinofuranoside hydrochloride, crystalline

Unit:100MG
List Price: £59.80
Source:List Price
ADD
C6645-1G
Cytosine beta-D-arabinofuranoside hydrochloride, crystalline

Unit:1G
List Price: £327.00
Source:List Price
ADD
C6645-500MG
Cytosine beta-D-arabinofuranoside hydrochloride, crystalline

Unit:500MG
List Price: £201.00
Source:List Price
ADD
C6645-5G
Cytosine beta-D-arabinofuranoside hydrochloride, crystalline

Unit:5G
List Price: £1,180.00
Source:List Price
ADD
Cas Number69-74-9
This product has met the following criteria: