C4911-50G Display Image

Chlorothiazide, thiazide diuretic

Code: C4911-50G D2-231

Application

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on block...


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£144.00 50G
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Application

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.

One of the first in the thiazide class of diuretics. The effect is sparing of calcium and lithium, but increases the excretion of sodium.

Biochem/physiol Actions

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration. CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.

General description

Chlorothiazide (CTLD) is a thiazide-like diureticsand has antihypertensive effects.

Packaging

50 g in glass bottle

assay≥98% (HPLC)
biological sourcesynthetic (organic)
formpowder
Gene Informationhuman ... CA1(759), CA4(762), SLC12A3(6559)
InChI keyJBMKAUGHUNFTOL-UHFFFAOYSA-N
InChI1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
mp>300 °C
Quality Level100
SMILES stringO=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
solubilityDMF: 50 mg/mL, clear, colorless to very faintly yellow
storage temp.2-8°C
Cas Number58-94-6
This product has met the following criteria: