Application

The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.

2-Hydroxylpropyl-β-cyclodextrin (HP-β-CD) is a hydroxyalkyl derivative used as formulation vehicle. It increases water solubility of the drug for successful delivery of medical agents to a biological system.HP-β-CD can be used:To increase the solubility of ropivacaine (RVC) upon complexation, which in turn enhances the pharmacological activity of RVC.To increase the aqueous solubility of naproxen (NAP) in presence of polyvinylpyrrolidone (PVP.As a template in the synthesis of hollow spherical copper sulfide nanoparticle assemblies.

Packaging

5, 25, 100 g in poly bottle

1 kg in poly drum