Application

Sodium thioglycolate has been used:as a growth supplement in enrichment media and to study its effect on Arcobacterin influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency lossin electron microscopy

Biochem/physiol Actions

Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth.

Caution

At room temperature, concentrations over 70% in water tend to form 1-2% thioglycolides per month which hydrolyze to the original free compound when made acidic or alkaline. The 70% solution oxidizes in air but is stable at room temperature when tightly closed. Thioglycolate salts may also lose purity on storage. The exclusion of air does not materially improve stability.

Packaging

25, 100, 500 g in poly bottle