F8514-5G Display Image

Flurbiprofen, cyclooxygenase inhibitor

Code: F8514-5G D2-231

Application

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used...


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Your Price
£232.00 5G
£278.40 inc. VAT

Application

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat and the biotransformation of flurbiprofen by Cunninghamella species.

Biochem/physiol Actions

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

Packaging

1, 5, 25 g in poly bottle

antibiotic activity spectrumfungi
assay≥98.5% (HPLC)
biological sourcesynthetic
colorwhite to off-white
formpowder
Gene Informationhuman ... ALB(213), APP(351), CYP1A2(1544), CYP2C9(1559), PTGS1(5742), PTGS2(5743)rat ... Ptgs1(24693)
InChI keySYTBZMRGLBWNTM-UHFFFAOYSA-N
InChI1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
mode of actionenzyme | inhibits
mp110-112 °C (lit.)
Quality Level100
SMILES stringCC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
solubilitymethanol: 50 mg/mL
Code
Description
Unit Size
List Price
Qty
F8514-1G
Unit:1G
List Price: £67.00
Source:List Price
ADD
F8514-25G
Unit:25G
List Price: £753.00
Source:List Price
ADD
Cas Number5104-49-4
Hazard Class6.1
Un Number2811
Pack GroupIII
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