Application

XAV939 has been used in the inhibition of tankyrase in neuroblastoma cell lines of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells of wnt signalling in human induced pluripotent stem cells (hiPSCs)

Biochem/physiol Actions

XAV939 is a Tankyrase inhibitor (thereby inhibiting Wnt / β-catenin signaling)

XAV939 is a cell-permeable dihydrothiopyranopyrimidinol, which elicits anti-tumor functionality against colon, lung, breast and liver cancer. It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.

Features and Benefits

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Other Notes

XAV939 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the XAV939 probe summary on the Chemical Probes Portal website.

Packaging

5, 25 mg in glass bottle