L7035-.1MG Display Image

clasto-Lactacystin beta-lactone,

Code: L7035-.1MG D2-231

Application

Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.

Clasto-Lactacystin β-lactone has been used as a protein degradation inhibitor to test...


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£499.00 EACH
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Application

Clasto-Lactacystin β-lactone has been used as a proteasomal inhibitor.

Clasto-Lactacystin β-lactone has been used as a protein degradation inhibitor to test its effect on memory improvements in mice. It has also been used as a proteasomeinhibitor in human ovarian surface epithelium (HOSE) cells and dendritic cells (DCs).

Biochem/physiol Actions

Cell-permeable and irreversible proteasome inhibitor. Lactacystin acts as a precursor for clasto-lactacystin β-lactone.

Clasto-Lactacystin β-lactone (cLβL) is synthesized from lactacystin. It is cell-permeable and cLβL acts on the N-terminal threonine of subunit proteasome β -subunit X It also inhibits 20S proteasome activity in Haloferax volcaniiby acting in the N-threonine residue of the β -type subunits.

assay≥95% (HPLC)
formfilm
InChI keyFWPWHHUJACGNMZ-NBBQQVJHSA-N
InChI1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
Quality Level100
SMILES string[H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
solubilityDMSO: soluble 25 mg/mL
storage temp.−20°C
Cas Number154226-60-5
Hazard Class6.1
Un Number2811
Pack Group3
This product has met the following criteria: