G3545-1MG Display Image

GW583340 dihydrochloride, >=97% (HPLC), solid

Code: G3545-1MG D2-231

Biochem/physiol Actions

Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC50= 0.01 and 0.014 µM for EGFR and ErbB-2. Orally active.

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£74.00 1MG

Biochem/physiol Actions

Potent dual ErbB-2/EGFR tyrosine kinase inhibitor. IC50= 0.01 and 0.014 µM for EGFR and ErbB-2. Orally active.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

assay≥97% (HPLC)
formsolid
InChI keyWIMITXDBYLKRKB-UHFFFAOYSA-N
InChI1S/C28H25ClFN5O3S2.2ClH/c1-40(36,37)10-9-31-14-27-35-25(16-39-27)19-5-7-24-22(12-19)28(33-17-32-24)34-21-6-8-26(23(29)13-21)38-15-18-3-2-4-20(30)11-18;;/h2-8,11-13,16-17,31H,9-10,14-15H2,1H3,(H,32,33,34);2*1H
mp259.8-262.4 °C (lit.)
originatorGlaxoSmithKline
Quality Level100
SMILES stringCl[H].Cl[H].CS(=O)(=O)CCNCc1nc(cs1)-c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2
solubilityDMSO: 9 mg/mL
storage temp.2-8°C
Cas Number0388082-81-3
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