Application

Chlorpromazine hydrochloride has been used:as an antagonists for calmodulin kinaseas a medium supplement to test its cytotoxic effects in human lung microvascular endothelial cells (HMVEC-L)as an inhibitor of clathrin-mediated endocytosis in RAW 264.7 cells

Substitute for benzidine, o-dianisidine, and o-tolidine in the determination of microquantities of hemoglobin and peroxidase.

Biochem/physiol Actions

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist, H₁ histamine receptor antagonist; inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase and nitric oxide synthase.

Chlorpromazine demonstrates cytotoxic and antiproliferative activity against leukemic cells, but does not affect the viability of normal lymphocytes.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

5, 25, 100 g in glass bottle