C5438-10MG Display Image

8-(4-Chlorophenylthio)-guanosine 3,5-cyclic monophosphate sodium salt, approx.95% (HPLC), powder

Code: C5438-10MG D2-231

Application

8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt has been used to activate GMP-dependent protein kinase (PKG) in vascular smooth muscle cel...


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£85.40 10MG
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Application

8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt has been used to activate GMP-dependent protein kinase (PKG) in vascular smooth muscle cells (VSMCs).

Biochem/physiol Actions

Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

10, 50 mg in poly bottle

assay≥95% (HPLC)
colorwhite
formpowder
InChI keyREEQGIQRCDWDRA-ZBMQJGODSA-M
InChI1S/C16H15ClN5O7PS.Na/c17-6-1-3-7(4-2-6)31-16-19-9-12(20-15(18)21-13(9)24)22(16)14-10(23)11-8(28-14)5-27-30(25,26)29-11;/h1-4,8,10-11,14,23H,5H2,(H,25,26)(H3,18,20,21,24);/q;+1/p-1/t8-,10-,11-,14-;/m1./s1
Quality Level200
SMILES string[Na+].NC1=Nc2c(nc(Sc3ccc(Cl)cc3)n2[C@@H]4O[C@@H]5COP([O-])(=O)O[C@H]5[C@H]4O)C(=O)N1
solubilityH2O: 25 mg/mL
storage temp.−20°C
Code
Description
Unit Size
List Price
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C5438-50MG
8-(4-Chlorophenylthio)-guanosine 3,5-cyclic monophosphate sodium salt, approx.95% (HPLC), powder

Unit:50MG
List Price: £278.00
Source:List Price
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Cas Number51239-26-0
This product has met the following criteria: