Application

Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) has been used:in the inhibition of efflux pump in clinical Pseudomonas aeruginosato inhibit oxidative phosphorylation activity of mitochondria in human Beas-2B bronchial epithelial cellsto prepare carbonyl cyanide m-chlorophenylhydrazone solution for oxidative and mitochondrial stress assay and mitophagy induction in Caenorhabditis elegans

Biochem/physiol Actions

Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) induces mitophagy in mammalian cells. CCCP suppresses the expression of few electron transport chain (ETC) proteins. Protonophore (H⁺ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. Shown to have a number of effects on cellular calcium. Inhibits secretion of hepatic lipase and partially inhibits the pH gradient-activated Cl^- uptake and Cl^-/Cl^- exchange activities in brush-border membrane vesicles.

Packaging

1 g in glass bottle

250 mg in glass bottle

100 mg in glass insert