Application
Cyclopiazonic acid fromPenicillium cyclopium has been used:as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)as a component in Ca2+-free DMEM/10% fetal bovine serum (FBS)as a reversible inhibitor of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi traffickingas an endoplasmic reticulum Ca2+-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca2+during Ca2+-induced Ca2+ release (CICR) to inhibit SERCA
Biochem/physiol Actions
Inhibits the sarcoplasmic reticulum Ca2+-pump.
General description
Cyclopiazonic acid (CPA), a tetramic acid is synthesized by various Aspergillus and Penicillium species.
Packaging
5, 10, 50 mg in glass bottle
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