Application

Cyclopiazonic acid fromPenicillium cyclopium has been used:as a standard in aflatoxin detection and quantification by thin layer chromatography (TLC)as a component in Ca²⁺-free DMEM/10% fetal bovine serum (FBS)as a reversible inhibitor of the sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) to examine the role of luminal calcium in endoplasmic recticulum (ER)-to-Golgi traffickingas an endoplasmic reticulum Ca²⁺-ATPase blocker, to treat neurons and also to study the role of the endoplasmic reticulum (ER) in releasing and sustaining Ca²⁺during Ca²⁺-induced Ca²⁺ release (CICR) to inhibit SERCA

Biochem/physiol Actions

Inhibits the sarcoplasmic reticulum Ca²⁺-pump.

General description

Cyclopiazonic acid (CPA), a tetramic acid is synthesized by various Aspergillus and Penicillium species.

Packaging

5, 10, 50 mg in glass bottle