C0621-5MG Display Image

CI-994, >=98% (HPLC), powder

Code: C0621-5MG D2-231

Application

CI-994 has been used:as an histone deacetylase (HDAC) inhibitor to treat SUM229 and DT22 cells to study its effectsas an HDAC inhibitor for screening in SPEL cell...


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Your Price
£115.00 5MG

Application

CI-994 has been used:as an histone deacetylase (HDAC) inhibitor to treat SUM229 and DT22 cells to study its effectsas an HDAC inhibitor for screening in SPEL cellsto study its effects on human myeloid and erythroid progenitors

Biochem/physiol Actions

CI-994 is the acetylated derivative form of the original compound Dinaline (PD 104 208). It is an oral cytostatic drug with impressive differential activity against leukemic cells & normal stem-cells. It is used for combination therapy for selected tumors including non-small cell lung, pancreatic, breast, and colorectal cancers. It acts as a histone deacetylase inhibitor. CI-994 blocks cells in the G1-S phase of the cell cycle. The 16 kDa phosphoprotein is confined to the nuclear compartment. Loss of the 16-kDa nuclear phosphoprotein appears to be a direct effect of CI-994 treatment and that the inhibition of this phosphoprotein may play a critical role in the mechanism of action of CI-994.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
coloroff-white
formpowder
Gene Informationhuman ... HDAC1(3065), HDAC10(83933), HDAC11(79885), HDAC2(3066), HDAC3(8841), HDAC4(9759), HDAC5(10014), HDAC6(10013), HDAC7(51564), HDAC8(55869), HDAC9(9734)
InChI keyVAZAPHZUAVEOMC-UHFFFAOYSA-N
InChI1S/C15H15N3O2/c1-10(19)17-12-8-6-11(7-9-12)15(20)18-14-5-3-2-4-13(14)16/h2-9H,16H2,1H3,(H,17,19)(H,18,20)
Quality Level100
SMILES stringCC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N
solubilityDMSO: >10 mg/mL
storage temp.room temp
Code
Description
Unit Size
List Price
Qty
C0621-25MG
Unit:25MG
List Price: £456.00
Source:List Price
ADD
Cas Number112522-64-2
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