Monoclonal Anti-RGS2 antibody produced in mouse, clone 4C4, purified immunoglobulin, buffered aqueous solution

Biochem/physiol Actions

Regulator of G-protein signaling 2 (RGS2) or G0/G1 switch regulatory gene 8 (GOS8) can decrease the activity of G protein through its GTPase actions. It acts as a GTPase activating protein (GAP) for G-protein (Gi). It might bind to adenylate cyclase to play an inhibitory role in Gs-mediated adenylate cyclase activity. RGS2 can block the proliferation of androgen-independent prostate cancer cells by inhibiting both constitutively activated extracellular signal-regulated kinases (ERKs) and androgen-independent androgen receptor (AR) activity. RGS2 is expressed at a high level in several solid breast cancers. Variation in the RGS2 gene might be involved in the development of anxiety in humans.

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General description

Regulator of G-protein signaling 2 (RGS2) or G0/G1 switch regulatory gene 8 (GOS8) protein belongs to the regulators of G-protein signaling (RGS) protein family of GTPase accelerating proteins (GAPs). Its mRNA expression is mainly seen in the brain, heart, lung, placenta, kidney, intestine, lymphocytes, and testis. RGS2 is located in the nucleus and the plasma membrane. RGS2 gene is located on human chromosome 1q31.2.

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis. (provided by RefSeq)

Immunogen

RGS2 (AAH07049, 111 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.SequenceEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT

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Physical form

Solution in phosphate buffered saline, pH 7.4