SAB2100069-100UL Display Image

Anti-AFF3

Code: SAB2100069-100UL D2-231

Biochem/physiol Actions

AF4/FMR2 family member 3 (AFF3) participates in transcriptional regulation. It is a potential clinical modulator of estrogen receptor (ER) signaling. ...


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£478.00 100UL
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Biochem/physiol Actions

AF4/FMR2 family member 3 (AFF3) participates in transcriptional regulation. It is a potential clinical modulator of estrogen receptor (ER) signaling. This transcription activator can play a role in lymphoid development and cancer. It can bind to double-stranded DNA in vitro. AFF3 overexpression causes tamoxifen resistance and estrogen-independent proliferation in ER+ human breast tumors.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

AF4/FMR2 family member 3 (AFF3), a tissue-restricted nuclear transcriptional activator, is mainly expressed in the lymphoid tissue. This RNA binding protein is a member of the AF4/LAF4/FMR2/AF5q31 family. AFF3 is a component of the transcriptional super elongation complex. It is expressed at a high level in the thymus. AFF3 has two domains with transactivation activity. This lymphoid-specific gene, is located on the human chromosome 2q11.2.

Immunogen

Synthetic peptide directed towards the middle region of human AFF3

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: APATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
concentration0.5 mg - 1 mg/mL
conjugateunconjugated
formbuffered aqueous solution
Gene Informationhuman ... AFF3(3899)
mol wt133 kDa
Quality Level100
shipped inwet ice
species reactivityhuman
storage temp.−20°C
technique(s)western blot: suitable
UniProt accession no.P51826
This product has met the following criteria: