Biochem/physiol Actions

The members of FGF (fibroblast growth factor) family take part in cell survival and mitogenic activities. FGFs are associated with a number of physiological processes such as cell growth, morphogenesis, embryonic development, tissue repair, tumor growth and invasion. FGF21 is a hormonal factor that regulates glucose homeostasis and energy metabolism. It possesses anti-diabetic properties by mediating glucose uptake in peripheral tissues. It also exhibits autocrine effects in white adipose tissue. FGF21 is present in milk and is needed for intestinal function in the neonate. It is also associated with bone loss. FGF21 is considered hepatoprotective in nature.

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General description

FGF (fibroblast growth factor) family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. The gene is mapped to human chromosome 19q13.33 and codes for a member of FGF superfamily. The encoded protein is produced in liver.

Immunogen

FGF21 (AAH18404.1, 1 a.a. ~ 209 a.a) full-length human protein.SequenceMDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAHLEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEACSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPAPPEPPGILAPQPPDVGSSDPLSMVGPSQGRSPSYAS

Physical form

Solution in phosphate buffered saline, pH 7.4