SAB1305776-400UL Display Image

ANTI-LC3 (APG8B) (T6)

Code: SAB1305776-400UL D2-231

Biochem/physiol Actions

MAP1LC3B-I (microtubule associated protein 1 light chain 3 β-I) associates with MAP1LC3B-II before being inserted into the inner and outer membranes o...


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£446.00 400UL
Discontinued

Biochem/physiol Actions

MAP1LC3B-I (microtubule associated protein 1 light chain 3 β-I) associates with MAP1LC3B-II before being inserted into the inner and outer membranes of the growing autophagic vesicle during autophagy. The cellular distribution and processing of MAP1LC3B facilitates monitoring of autophagy. Cells that lack MAP1LC3B are found to be defective in the formation of autophagic vesicles, with altered phenotypes associated with the role of autophagy in energy homeostasis and removal of protein aggregates. MAP1LC3B can serve as an autophagic marker.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

LC3B or MAP1LC3B (microtubule associated protein 1 light chain 3 β) is a homolog of the ATG8 gene, which is an autophagy-related gene in yeast. The encoded protein is called pro-MAP1LC3B, a pro-form that is cleaved by ATG4 to produce a cytosolic form called MAP1LC3B-I.

Physical form

Supplied in PBS with 0.09% (W/V) sodium azide

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
formbuffered aqueous solution
Gene Informationhuman ... MAP1LC3B(81631)
mol wt14688 Da
NCBI accession no.NP_073729.1
Quality Level100
shipped inwet ice
species reactivityhuman, mouse
storage temp.−20°C
technique(s)western blot: 1:1000
UniProt accession no.Q9GZQ8
This product has met the following criteria:



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