Anti-Rat MKP3 antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

General description

Dual specificity protein tyrosine phosphatases (dsPTPs) are a subfamily of protein tyrosine phosphatases implicated in the regulation of mitogen-activated protein kinase (MAPK). MKP-1 (also known as CL100, 3CH134, Erp, and hVH-1) exemplifies a class of dual-specificity phosphatase able to reverse the activation of MAP kinases by dephosphorylating critical tyrosine and threonine residues. MKP-3 is 36% identical to MKP-1 and it blocks both the phosphorylation and enzymatic activation of ERK2 by mitogens. MKP-3 mRNA is expressed in lung, heart, brain, and kidney, but not significantly in skeletal muscle or testis

Immunogen

RAT MKP3 (1-410)This antibody is generated from rabbits immunized with a 6xHIS-tagged recombinant protein encoding aa 1-381 of rat MKP3.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.