Anti-Potassium Channel K2P1.1 (TWIK-1) antibody produced in rabbit, affinity isolated antibody, lyophilized powder

Biochem/physiol Actions

The gene KCNK1 (potassium two pore domain channel subfamily K member 1) is a double-pore potassium channel that functions in maintaining the renal potassium homeostasis. KCNK channel proteins are involved in cell volume, apoptosis, and proliferation. Alterations in these proteins have been associated with various diseases. Decreased levels of KCNK1 in human cardiac atria have been implicated in chronic atrial fibrillation. It functions as a suppressor of anchorage-independent growth in fibroblast.

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General description

The gene K2P1.1 (two pore domain K⁺ channel), also referred to as KCNK1 (potassium two pore domain channel subfamily K member 1), encodes a protein that spans a length of 337-amino acids. It contains four transmembrane regions and the characteristic sequence of potassium channels in the two pore regions. The protein is found to be exclusively expressed in distal tubule. The gene is mapped to human chromosome 1q42.2.

Immunogen

synthetic peptide RQELRKLKRRFLEEHEC, corresponding to amino acid residues 53-69 of human K_2P1.1 (KCNK1).

Physical form

Lyophilized from pphosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

Reconstitution

Reconstitute the lyophilized vial with 50 µL or 200 µL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

Target description

K_2P1.1 (also named TWIK-1 or KCNK1) is a member of the 2-pore (2P) domain K⁺ channels family that at the moment includes 14 members. These channels show little time or voltage dependence and are considered to be "leak" or "background" K⁺ channels, thereby generating background currents, which help set the membrane resting potential and cell excitation.