Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product does not compete with ATP.

Primary TargetNADH-CoQ reductase

General description

A mitochondrial toxin and a potent, reversible, and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain. Also inhibits cellular proliferation in mouse liver.

A mitochondrial toxin and a potent, reversible and competitive inhibitor of complex I (NADH-CoQ reductase) of the respiratory chain. Also inhibits cellular proliferation in mouse liver.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Kopustinskiene, D.M., et al. 2001. Eur. J. Pharmacol.428, 311.Higgins, D.S., Jr. and Greenamyre, J.T. 1996. J. Neurosci. 16, 3807.Cunningham, M.L., et al. 1995. Cancer Lett. 95, 93.

Packaging

Packaged under inert gas

1 g in Glass bottle

Reconstitution

Following reconstitution, aliquot, flush with nitrogen, and store at -70°C. Stock solutions are stable for up to 1 month at -70°C.

Warning

Toxicity: Toxic (F)