Biochem/physiol Actions
Reversible: yes
Primary TargetRAGE
General description
An S100P-derived peptide based competitive antagonist for receptor for advanced glycation end product (RAGE). Shown to disrupt the interaction between RAGE and its ligands, such as S100P, S100A4 and HMGB-1 in binding assays and in multiple cancer cell lines (~2 µM). Also, blocks RAGE-dependent NF-kB activation in MPanc96, MOH and HPAF II tumor cell lines. Systemic administration of RAP also diminishes NF-kB signaling in vivo and significantly reduces glioma tumor growth in murine models.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Arumugam, T., et al. 2012. Clin Cancer Res.18, 4356.
Packaging
Packaged under inert gas
10 mg in Glass bottle
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Sequence
Ac-ELKVLMEKEL-NH2
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria: