Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Target IC₅₀: 2-50 µM against cAMP and cGMP phosphodiesterases

Primary TargetcAMP and cGMP phosphodiesterases

Cell permeable: yes

General description

A non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.

A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀ = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Hube, F., et al. 1999. Horm. Metab. Res.31, 359.Morgan, A.J., et al. 1993. Biochem. Pharmacol.45, 2373.Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci.11, 150.Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA76, 4451.

Packaging

1 g in Plastic ampoule

250 mg in Plastic ampoule

Preparation Note

Heating may be required to achieve complete solubilization.

Reconstitution

Following reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.

Warning

Toxicity: Standard Handling (A)