Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product competes with ATP.

Primary TargetProtein kinase C

Target K_i: 10 nM against protein kinase C

General description

A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). Inhibits protein kinase A at much higher concentrations (K_i = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).

An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (K_i = 10 nM). May inhibit protein kinase A at much higher concentrations (K_i = 2 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Le Panse, R., et al. 1994. Mol. Pharmacol.46, 445.Kuchera, S., et al. 1993. Agents Actions 39, C169.Wilkinson, S.E., et al. 1993. Biochem. J.294, 335.Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

Packaging

1 mg in Plastic ampoule

250 µg in Plastic ampoule

Reconstitution

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Warning

Toxicity: Standard Handling (A)