F8557-5MG Display Image

FK866 hydrochloride hydrate, >=98% (HPLC)

Code: F8557-5MG D2-231

Application

FK866 hydrochloride hydrate has been used:to investigate its effects on intra-axonal NAD+ levelsto induce NAD+ depletionto reduce the level of tumor ne...


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Your Price
£155.00 5MG
£186.00 inc. VAT

Application

FK866 hydrochloride hydrate has been used:to investigate its effects on intra-axonal NAD+ levelsto induce NAD+ depletionto reduce the level of tumor necrosis factor-α (TNF-α), nicotinamide phosphoribosyltransferase (NAMPT) and interleukin-6 (IL-6) in the ischemic brain tissue

Biochem/physiol Actions

FK866 is a potent inhibitor of NAD biosynthesis, and a specific inhibitor of NAMPT (Nicotinamide Phosphoribosyltransferase, visfatin, PBEF). NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAMPT also acts as a cytokine independent of its enzymatic activity, playing a major part in regulating immune responses.

General description

FK866 is used to treat inflammatory diseases and cancer.

Packaging

5, 25 mg in glass bottle

assay≥98% (HPLC)
colorwhite to beige
formpowder
Quality Level100
solubilityDMSO: 10 mg/mL, clear
storage conditiondesiccated
storage temp.−20°C
Code
Description
Unit Size
List Price
Qty
F8557-25MG
Unit:25MG
List Price: £566.00
Source:List Price
ADD
Cas Number658084-64-1
This product has met the following criteria: