T2067-5MG Display Image

Tyrphostin AG 879, 99% (HPLC)

Code: T2067-5MG D2-231

Application

Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can caus...


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£190.00 5MG
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Application

Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2.

Biochem/physiol Actions

Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).

Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

5 mg in glass bottle

Preparation Note

Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.

assay99% (HPLC)
Gene Informationhuman ... ERBB2(2064), NTRK1(4914)
InChI keyXRZYELWZLNAXGE-KPKJPENVSA-N
InChI1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+
Quality Level100
SMILES stringCC(C)(C)c1cc(C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C
solubilityDMSO: soluble (at 26 mg/ml), H2O: insoluble
Cas Number148741-30-4
This product has met the following criteria: