Analysis Note

Purity by agarose gel electrophoresis.

Application

Holo-Transferrin bovine has been used:as a RPMI-1640 medium supplement for culturing cancer cell lines as a component of visceral fat differentiation medium for the pre-adipocytes primary cell cultureto test the influence of iron-saturation complex on the growth of Malassezia pachydermatisas a standard for strong anion exchange (SAX) reactor measurements

Biochem/physiol Actions

Studies show that treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.

Holo-Transferrin (holo-Tf) or the iron bound transferrin functions as an iron sequester and is crucial for defense against microbial infections. Transferrin is used as a model system for understanding the kinetics and dynamics of protein structure based interactions. It is a potential candidate for delivery studies for its ability to cross the blood-brain barrier. The interaction of holo-Tf with thrombin is implicated in the pathogenesis of intracerebral hemorrhage. Polymorphisms in the bovine transferrin gene has led to the generation of 10 variant transferrin protein.

General description

Holo-Transferrin is an iron transporting glycoprotein and belongs to metalloprotein class. The gene encoding transferrin is mapped to bovine chromosome 1.

Packaging

1 g in poly bottle

50, 500 mg in poly bottle