SML1279-5MG Display Image

LLY-507

Code: SML1279-5MG D2-231

Biochem/physiol Actions

LLY-507 is a potent and selective inhibitor of SMYD2 protein lysine methyltransferase (PKMT) with an in vitro IC50 ﹤15 nM a...


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£179.00 5MG
£214.80 inc. VAT
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Biochem/physiol Actions

LLY-507 is a potent and selective inhibitor of SMYD2 protein lysine methyltransferase (PKMT) with an in vitro IC50 ﹤15 nM and >100-fold selectivity over other methyltransferases and other non-epigenetic targets. LY-507 has been shown to inhibit p53K370 monomethylation in cells with an IC50 ~600 nM. For full characterization details, please visit the LLY-507 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

LLY-507 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

LLY-507 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the LLY-507 probe summary on the Chemical Probes Portal website.

Packaging

5, 25 mg in glass bottle

assay≥97% (HPLC)
colorwhite to beige
formpowder
InChI keyPNYRDVBFYVDJJI-UHFFFAOYSA-N
InChI1S/C36H42N6O/c1-28-27-42(34-11-4-2-9-32(28)34)22-19-40-17-20-41(21-18-40)35-12-5-3-10-33(35)30-23-29(26-37)24-31(25-30)36(43)38-13-8-16-39-14-6-7-15-39/h2-5,9-12,23-25,27H,6-8,13-22H2,1H3,(H,38,43)
Quality Level100
SMILES stringCC(C1=C2C=CC=C1)=CN2CCN(CC3)CCN3C4=CC=CC=C4C5=CC(C#N)=CC(C(NCCCN6CCCC6)=O)=C5
solubilityDMSO: 5 mg/mL, clear (warmed)
storage temp.2-8°C
This product has met the following criteria: