Oligomycin from Streptomyces diastatochromogenes, oligomycin A basis; total oligomycins basis (HPLC), >=60% oligomycin A basis, >=90% total oligomycins basis (HPLC)

Code: O4876-5MG D2-231

Application

Oligomycin from Streptomyces diastatochromogenes is used:in the inhibition of mitochondrial ATP production Leigh syndrome (LS) cells.in ATP-linked respir...

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Application

Oligomycin from Streptomyces diastatochromogenes is used:in the inhibition of mitochondrial ATP production Leigh syndrome (LS) cells.in ATP-linked respiration and maximal capacity respiration assay in astrocytes.in measurement of oxygen consumption rate (OCR) and extracellular acidification rates in breast cancer cell lines.

Biochem/physiol Actions

Oligomycin belongs to the macrolide group of antibiotics. It inhibits mitochondrial ATP-synthase enzyme and phosphoryl group transfer. Oligomycin interacts with ATP synthase subunit-c in the Fo portion and impairs proton transport.

General description

Chemical structure: macrolide

Other Notes

A mixture of oligomycins A, B, and C.

Packaging

5 mg in glass bottle

100, 250 mg in glass bottle

25 mg in poly bottle

antibiotic activity spectrum	fungi
assay	≥90% total oligomycins basis (HPLC)
form	powder
InChI key	MNULEGDCPYONBU-ZUSSGZTJSA-N
InChI	1S/C45H74O11/c1-12-34-17-15-13-14-16-27(4)42(51)44(11,53)43(52)32(9)40(50)31(8)39(49)30(7)38(48)26(3)18-21-37(47)54-41-29(6)35(20-19-34)55-45(33(41)10)23-22-25(2)36(56-45)24-28(5)46/h13-15,17-18,21,25-36,38,40-42,46,48,50-51,53H,12,16,19-20,22-24H2,1-11H3/b14-13+,17-15-,21-18+
mode of action	enzyme \| inhibits
Quality Level	200
storage temp.	−20°C