Application

Mifepristone has been used:to induce damage against the proliferative and secretory phase of endometrial stromal cellsto establish a preterm birth (PTB) mice model in order to study the difference in cervical ripening mechanism between term and PTBs to activate geneswitch gal4 in flies to study the effects of sex steroids on prostaglandin secretion

Biochem/physiol Actions

Mifepristone (RU-486) has activity as both a progesterone receptor antagonist and a glucocorticoid receptor antagonist.

Therefore, mifepristone is considered to be a potent abortifacient. It is also known to inhibit human chorionic gonadotropin. Mifepristone results in decidual necrosis.

Features and Benefits

This compound was developed by Danco Laboratories. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Packaging

1 g in glass bottle

100, 500 mg in glass bottle