Application
Hck is a protein-tyrosine kinase that is expressed in hemopoietic cells. It is used in leukemia research .
Biochem/physiol Actions
Hck is a member of the Src tyrosine kinase family. Hck has been shown to associate with and be activated by Bcr-Abl, which is a protein-tyrosine kinase that is expressed in chronic myelogenous leukemia .
Physical form
Supplied as a solution in 50 mM Tris HCl, pH 7.4, 1 mM EDTA and 1 mM DTT
Unit Definition
One unit will phosphorylate 1.0 picomole of Tyr15 of the peptide substrate pcdc2 6-20 per minute at 30 °C at pH 7.4.
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