A5282-25MG

Application

DL-2-Amino-5-phosphonopentanoic acid has been used:• in the inactivation of N-methyl-D-aspartate (NMDA)-mediated synapses• used in growth medium for inhibition of electrical activity in the neuronal network• used to isolate N-methyl-D-aspartate receptors (NMDAR) or a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-mediated currents were isolated using this product• used in double distilled water to compare its NMDA antagonistic action with that of prion protein (PrPC)

Biochem/physiol Actions

Anticonvulsant; potent and selective NMDA receptor antagonist.

Caution

Hygroscopic

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC^®¹²⁸⁰), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Packaging

10, 25, 50, 100 mg in glass bottle

InChI key	VOROEQBFPPIACJ-UHFFFAOYSA-N
InChI	1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)
solubility	H₂O: 5.6 mg/mL
solubility	organic solvents: insoluble
solubility	0.1 M NaOH: 4 mg/mL
form	solid
color	white
SMILES string	NC(CCCP(O)(O)=O)C(O)=O
Gene Information	rat ... Grik1(29559), Grin2a(24409), Grin2b(24410)