Application

18:1 PI(4,5)P2 is suitable to use as a supplement in native macrophage membranes to generate phospholipid enriched membrane liposome.s It has also been used:in the preparation of anionic phospholipid liposomesas a component in supported membrane tube (SMrT) templatesin liposome preparation

Biochem/physiol Actions

Phosphatidylinositol bisphosphate (PIP2) can effectively stimulate the ATPase.

General description

Phosphatidylinositol is a structuralphospholipid. Phosphatidylinositolphosphate(PIP) is located in the plasma membrane.

Although PI(4,5)P2 is a minor component of cell membranes, it plays a critical role as a substrate for a number of important signaling proteins. PI(4,5)P2 is an intermediate in the IP3/DAG pathway where it is hydrolyzed by phospholipase C to liberate the second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). PI(4,5)P2 is also a substrate for PI 3-kinase where it is phosphorylated to PI(3,4,5)P3, an activator of downstream signaling components such as the protein kinase AKT.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-500ug)

2 mL Amber Serum Vial with Stopper and Crimp Cap (850155P-100ug)