Application

N-[3,5-Bis(trifluoromethyl)phenyl]-N′-[(8a,9S)-6′-methoxy-9-cinchonanyl]thiourea is a bifunctional cinchona organocatalyst, which can be used to synthesize: Stereoselective diaryl(nitro)butanone via enantioselective Michael addition of nitromethane to chalcones. Enantioselective β-amino acids via asymmetric Mannich reaction of malonates with aryl and alkyl imines. The synthesis of 3-indolylmethanamines by the reaction of indoles with imines via asymmetric Friedel-Crafts reaction. The enantioselective conjugate addition of active methylene compounds to enones to obtain the corresponding addition products.

Packaging

250 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.