44583-10MG Display Image

Doxorubicin hydrochloride, (HPLC), suitable for fluorescence, 98.0-102.0% (HPLC)

Code: 44583-10MG D2-231

Application

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

Biochem...

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£265.00 10MG
List Price

Application

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.

Biochem/physiol Actions

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .

General description

Chemical structure: tetracycline

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Packaging

1, 10, 50 mg in glass bottle

Bottomless glass bottle. Contents are inside inserted fused cone.

solubilityH2O: 50 mg/mL, clear, orange to red
solubilityTHF: soluble
solubilitymethanol: soluble
solubilityethanol: soluble
solubilityDMSO: soluble
mp216 °C (dec.) (lit.)
antibiotic activity spectrumneoplastics
Quality Level200
storage temp.2-8°C
colororange to dark red
fluorescenceλex 470 nm; λem 585 nm in ethanol
SMILES stringCl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
Mode of actionenzyme | inhibits
Mode of actionDNA synthesis | interferes
biological sourcesynthetic
assay98.0-102.0% (HPLC)
formsolid
InChI keyMWWSFMDVAYGXBV-RUELKSSGSA-N
suitabilitysuitable for fluorescence
InChI1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1

Code
Description
Unit Size
List Price
Qty
44583-1MG
Unit:1MG
List Price: £52.80
Source:List Price
ADD
44583-50MG
Unit:50MG
List Price: £982.00
Source:List Price
ADD
Cas Number25316-40-9