345R-16 Display Image

Uroplakin III (SP73); 1ml; con

Code: 345R-16 D2-231

General description

Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-ne...


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£1,691.95 EACH

General description

Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. In non-neoplastic mammalian urothelium, UPs are expressed in the luminal surface plasmalemma of superficial (umbrella) cells, forming complexes of 16nm crystalline particles. Anti-UPIII was detectable immunohistochemically in 29 of 55 primary (53%) and 23 of 35 metastatic (66%) urothelial carcinomas, whereas many non-urothelial carcinomas were anti-UPIII negative. The authors concluded that anti-UPIII should be a valuable marker, especially for the specific identification of urothelial carcinomas in patients with metastases of unknown primary site. Olsburgh et al. studied anti-UPIII gene expression in normal urothelium and bladder cancer specimens, and found that expression was absent after malignant transformation. Thus, UP expression might reflect the malignant potential of urothelial cancer cells as well as being cytodifferential markers of urothelial cells. Ohtsuka et al. concluded in their studies that anti-UPIII expression was strongly associated with lower tumor grades, that lack of UPIII expression in urothelial tumors of the upper urinary tract was associated with much higher rates of metastases, and that 5-year specific survival was much worse for anti- UPIII negative tumors (54%) than for anti-UPIII positive tumors (100%). Apparently, UPIII expression characteristics are a better indicator of the malignant potential of urothelial carcinomas than the grade of these tumors.

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

Linkage

Uroplakin III Positive Control Slides, Product No. 345S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and ﹤0.1% Sodium Azide

Preparation Note

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antibody formculture supernatant
antibody product typeprimary antibodies
biological sourcerabbit
cloneSP73, monoclonal
conjugateunconjugated
controlbladder
descriptionFor In Vitro Diagnostic Use in Select Regions (See Chart)
formbuffered aqueous solution
Gene Informationhuman ... UPK3A(7380)
isotypeIgG
manufacturer/tradenameCell Marque
packagingbottle of 1.0 mL predilute (345R-17), vial of 1.0 mL concentrate (345R-16), vial of 0.1 mL concentrate (345R-14), vial of 0.5 mL concentrate (345R-15), bottle of 7.0 mL predilute (345R-18)
Quality Level100, 500
shipped inwet ice
species reactivityhuman
storage temp.2-8°C
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:1000
visualizationmembranous
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345R-14
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345R-15
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345R-17
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List Price: £177.36
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345R-18
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