Cell permeable: no
EC50 = 4 µM increasing the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum
Product does not compete with ATP.
Primary TargetActivator Protein-1 (AP-1)
Phytochemical compound isolated from the extract of rhizome of ginger. Along with other related compounds found in ginger extracts inhibits prostaglandin and leukotriene biosynthesis through the suppression of 5-lipoxygenase and prostaglandin synthetase. Also exhibits anti-tumor and apoptosis-inducing effects. Blocks EGF-induced cell transformation by inhibiting the activation of Activator protein-1 (AP-1). Shown to inhibit the EGF-induced, sequence-specific DNA-binding of AP-1. Does not effect EGF-induced phosphorylation of ERK or p38 kinases. Also increases the Ca2+-ATPase activity of the sarcoplasmic reticulum (EC50 = 4 µM).
An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). Also increases the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum (EC50 = 4 µM) and increases Ca2+ uptake.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Bode, A.M., et al. 2001. Cancer Res.61, 850.Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther.290, 227.Park, K.K.,et al. 1998. Cancer Lett.129, 139.Kobayashi, M., et al. 1987. Biochim. Biophys. Acta903, 96.
Packaged under inert gas
5 mg in Plastic ampoule
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.
Toxicity: Harmful (C)