Biochem/physiol Actions

Cell permeable: no

Reversible: no

EC50 = 4 µM increasing the Ca2+-ATPase activity in cardiac sarcoplasmic reticulum

Product does not compete with ATP.

Primary TargetActivator Protein-1 (AP-1)

General description

Phytochemical compound isolated from the extract of rhizome of ginger. Along with other related compounds found in ginger extracts inhibits prostaglandin and leukotriene biosynthesis through the suppression of 5-lipoxygenase and prostaglandin synthetase. Also exhibits anti-tumor and apoptosis-inducing effects. Blocks EGF-induced cell transformation by inhibiting the activation of Activator protein-1 (AP-1). Shown to inhibit the EGF-induced, sequence-specific DNA-binding of AP-1. Does not effect EGF-induced phosphorylation of ERK or p38 kinases. Also increases the Ca²⁺-ATPase activity of the sarcoplasmic reticulum (EC₅₀ = 4 µM).

An antitumor, apoptosis-inducing compound of the ginger family that blocks EGF-induced cell transformation by inhibiting the activation of Activator Protein-1 (AP-1). Also increases the Ca²⁺-ATPase activity in cardiac sarcoplasmic reticulum (EC₅₀ = 4 µM) and increases Ca²⁺ uptake.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bode, A.M., et al. 2001. Cancer Res.61, 850.Antipenko, A.Y., et al. 1999. J. Pharmacol. Exp. Ther.290, 227.Park, K.K.,et al. 1998. Cancer Lett.129, 139.Kobayashi, M., et al. 1987. Biochim. Biophys. Acta903, 96.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months -20°C.

Warning

Toxicity: Harmful (C)