Analysis Note
Single spot by TLC
Biochem/physiol Actions
Reversible: no
Primary TargetProtein kinase C
Cell permeable: yes
General description
Cell-permeable activator of protein kinase C; however, it has lower affinity for PKCa than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.
Cell-permeable activator of protein kinase C (PKC). Exhibits lower affinity for PKCα than for other isozymes. Shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.Davis, R.J. 1985. J. Biol. Chem.260, 1562.
Packaging
Packaged under inert gas
10 mg in Plastic ampoule
Reconstitution
Unstable in solution; reconstitute just prior to use.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria: