Castanospermine; Castanospermum australe

Biochem/physiol Actions

Cell permeable: no

Primary Targetβ-glucosidases

Reversible: no

Product does not compete with ATP.

General description

Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu₃Man_7-9 (GlcNAc)₂. Inhibits endothelial cell angiogenesis and tumor growth. Exhibits anti-viral properties. Typically used at 1-10 µg/ml.

Plant alkaloid inhibitor of several β-glucosidases and α-glucosidases, including those involved in N-linked processing of glycoproteins. Resulting oligosaccharides are primarily Glu₃Man_7-9(GlcNAc)₂. Reduces bFGF induced angiogenesis in mice. Inhibits endothelial cell migration and invasion of basement membrane. Exhibits anti-viral properties. Typically used at 1-10 µg/ml.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ahmed, S.P., et al. 1995. Biochem. Biophys. Res. Commun. 208, 267.Pili, R., et al. 1995. Cancer Res.55, 2920.Walker, B.D., et al. 1987. Proc. Natl. Acad. Sci. USA84, 8120.Pan, Y.T., et al. 1983. Biochemistry22, 3975.Saul, R., et al. 1983. Arch. Biochem. Biophys. 221, 593.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Warning

Toxicity: Harmful (C)