Biochem/physiol Actions

Primary TargetGlycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex

Target IC₅₀: 38 nM in blocking 3H-glycine binding to rat forebrain membrane; 131 µM in blocking NMDA-induced release of arachidonic acid; 131 µM in cerebellar granule cells

General description

An agonist for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Mimics the effects of glycine on the NMDA receptor ion channel and blocks ³H-glycine binding to rat forebrain membrane (IC₅₀ = 38 nM). Blocks NMDA-induced release of arachidonic acid (IC₅₀ = 131 µM) in cerebellar granule cells. Reduces NMDA-induced cell death in hippocampal neurons.

A potent and selective ligand for the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. Blocks ³H-glycine binding to rat forebrain membranes (IC₅₀ = 38 nM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Viu, E., et al. 1998. J. Pharm. Exp. Ther.285, 527.Zapata, A., et al. 1996. NeuroReport7, 397.Kolesnikov, Y.A., et al. 1994. Life Sci. 55, 1393.Rottmann, W.H., et al. 1991. J. Mol. Biol.222, 937.Marvizon, J.C., et al. 1989. J. Neurochem.52, 992.Nadler, V., et al. 1988. Eur. J. Pharmacol.157, 115.Adams, D.O., and Yang, S.F. 1979. Proc. Natl. Acad. Sci. USA76, 170.

Packaging

250 mg in Glass bottle

1 g in Glass bottle

Preparation Note

May require heating and sonication to achieve complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Warning

Toxicity: Irritant (B)