Biochem/physiol Actions

Primary TargetGPR55 receptor

General description

An endogenous lipid that acts as a selective agonist for GPR55 receptors (EC₅₀ = 4, 19 800 and >30 000 nM at GPR55, CB₂ and CB₁ receptors respectively). Producing robust anti-inflammatory actions by activating PPARα (EC₅₀ = 3 µM).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Griffin, G., et al. 2000. J. Pharmacol. Exp. Ther.292, 886.r>Lambert, D., et al. 2001. Epilepsia.42, 321.Lambert, D., et al. 2002. Curr. Med. Chem.9, 663.Lo Verme, J., et al. 2005. Life Sci.77, 1685.Re, G., et al. 2005. Vet. J.173, 21.Ryberg, R., et al. 2007. Br. J. Pharmacol.152, 1092.

Preparation Note

Slight warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Warning

Toxicity: Standard Handling (A)