Biochem/physiol Actions

Cell permeable: no

Primary TargetMetalloproteases

Reversible: yes

General description

A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM. The solid form of this compound (Cat. No. 200484) is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Merck Index: 14, 9842.Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab.79, 171.Taylor, A., et al. 1993. Biochemistry32, 784.Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.

Packaging

Packaged under inert gas

10 mg in Glass bottle

Physical form

Supplied as a 50 mM (10 mg/580 µL) solution of Bestatatin, HCl in H₂O.

Reconstitution

Following initial, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Warning

Toxicity: Standard Handling (A)