ABS1494-100UG Display Image


Code: ABS1494-100UG D2-231


Research CategorySignaling

Anti-SCYL1, Cat. No. ABS1494, is a rabbit polyclonal antibody that detects SCY1-Like Protein 1 and has been tested for use in Imm...

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£458.00 100UG


Research CategorySignaling

Anti-SCYL1, Cat. No. ABS1494, is a rabbit polyclonal antibody that detects SCY1-Like Protein 1 and has been tested for use in Immunocytochemistry and Western Blotting.

Immunocytochemistry Analysis: A 1:100 dilution from a representative lot detected SCYL1 in HeLa, A431, HUVEC, and NIH/3T3 cells.


Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

N-terminal kinase-like protein (UniProt: Q96KG9; also known as Coated vesicle-associated kinase of 90 kDa, SCY1-like protein 1, Telomerase regulation-associated protein, Telomerase transcriptional element-interacting factor, Teratoma-associated tyrosine kinase) is encoded by the SCYL1 (also known as CVAK90, GKLP, NTKL, TAPK, TEIF, TRAP, HT019) gene (Gene ID: 57410) in human. SCY1-like protein 1 is ubiquitously expressed and it regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. It is involved in the maintenance of the Golgi apparatus morphology. It has a divergent N-terminal kinase domain (aa 14-314), but it is catalytically inactive. It also contain three HEAT repeats (aa 350-388; 389-427; and 507-545). Six isoforms of SCY1-like protein 1 have been reported that are produced by alternative splicing. Its intracellular distribution is isoform specific. Isoforms 1 and 2 are shown to be cytoplasmic throughout the cell cycle. Isoform 3 is cytoplasmic during interphase and centrosomal during mitosis. Isoform six is generally localized to nucleus and it acts as a transcriptional activator and binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. Mutations in SCYL1 gene are reported to cause Spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord.


Epitope: C-terminus

KLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminal region of human SCY1-Like Protein 1.

Other Notes

Concentration: Please refer to lot specific datasheet.

Physical form

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Affinity Purified


Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected SCY1-Like Protein 1 (SCYL1) in HeLa cell lysate.


This rabbit polyclonal antibody detects SCY1-Like Protein 1 (SCYL1) in human cells. It targets an epitope within 16 amino acids from the C-terminal region. The immunogen is conserved between isoforms 1, 2, and 3.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~100 kDa observed; 89.63 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
Gene Informationhuman ... SCYL1(57410)
NCBI accession no.NP_001041683.1
packagingantibody small pack of 25 µg
purified byaffinity chromatography
species reactivityhuman, mouse
technique(s)immunocytochemistry: suitable, western blot: suitable
UniProt accession no.Q96KG9
Unit Size
List Price
List Price: £149.00
Source:List Price
Est. Dispatch/Availability