Biochem/physiol Actions

Minichromosome maintenance complex component 8 (MCM8) is one of the mini-chromosome maintenance proteins that are crucial for eukaryotic genome replication. MCM proteins are key components of the pre-replication complex, recruit replication-related proteins and form replication forks. MCM8 complexes with MCM9 to recruit RAD51 at the sites of DNA damage to facilitate homologous recombination.

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Immunogen

Synthetic peptide directed towards the C terminal region of human MCM8

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Sequence

Synthetic peptide located within the following region: IRLTEARARLELREEATKEDAEDIVEIMKYSMLGTYSDEFGNLDFERSQH